Comfortech | LCMS-IT-TOF
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LCMS-IT-TOF

Enabling LC/MSn high-precision mass analysis, Shimadzu’s LCMS-IT-TOF is a novel hybrid mass spectrometer for biomarker discovery, metabolite identification and human health research, and ideal for applications in forensics, drug development, and environmental chemistry. Coupling atmospheric pressure ionization with Ion-Trap (IT) and Time-of-Flight (TOF) technologies, the LCMS-IT-TOF delivers high mass accuracy and high mass resolution (10,000 at 1000 m/z) independent of MS mode.
The LCMS-IT-TOF has been designed to maximize sensitivity and selectivity by optimizing the ion transport to the TOF analyzer and redefining the capability of the quadrupole ion trap. The ion trap is used to focus ions before ejection into the TOF as well as supporting MSn analysis with effective precursor ion selection capabilities (resolution > 1,000 at 1,000 m/z).

Features

 

The LCMS-IT-TOF allows more qualitative information about a sample to be collected in a single run, enabling researchers and scientists to:

 

•Elucidate structures of new molecules
•Identify impurities and contaminants
•Analyze metabolites and biomarkers to evaluate biological pathways
•Predict accurate structural details
•Obtain high-sensitivity detection of low concentration samples

 

To accomplish these objectives, the LCMS-IT-TOF incorporates a host of new technologies and enhancements, including:

Compressed Ion Injection” (CII) (patented) 
The CII method makes it possible to control the accumulation of ions before they are introduced into the ion trap. Adopted for the LCMS-IT-TOF, it effectively couples the LC system to the MS, dramatically increasing sensitivity.

Ballistic Ion Extraction (BIE) (patented)
The use of BIE accelerates ions into the TOF instantly, and combined with the Dual-Stage Reflectron (DSR) (patented), achieves faster, more stable, and higher resolution spectra.

Temperature Control of the Flight Tube
In concert with the localized ion due to BIE from the QIT and the 10bit high-speed transient recorder, the temperature control mechanism of the flight tube enables extended stability in mass accuracy.

High-speed Ion Polarity Switching
Utilizing a newly developed, accurate and stable power supply, in combination with an innovative high-voltage switch, allows for polarity switching in only 0.1 sec or less.

Software

 

Formula Predictor Software 
Using information-rich MSn data, the patent-pending Formula Predictor software takes advantage of multiple levels of fragmentation, isotope pattern verification, and unique fragment-ion filtering techniques to accurately determine the correct formula for unknown components.
Traditional approaches for deducing empirical formulae from mass spec data often depend on very high mass accuracy, which carries a correspondingly high cost, and considerable time input from the user to eliminate low-probability structures. Shimadzu´s new system reduces or eliminates this need for tedious, manual processing of target candidates. In many cases, the software can reduce the collection of target compounds from a high number of possible candidates to predicting the most likely empirical formula with just a simple mouse click.

 

 

Metabolite Profiling Software 
Quickly extracts and compares data obtained from complex biological samples, and then links them with identifications.

 

 

Protein Analysis Software 
Generates information-rich MS/MS spectra to help identify proteins. Simply set the peak-list generation and database search parameters for automated protein identification, and quickly link the data to a MASCOT search

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